Growth Hormone Releasing Peptides or GHRPs

Growth Hormone Releasing Peptides or GHRPs

Growth Hormone Releasing Peptides, commonly known as GHRPs, are not approved for human use by the FDA and therefore should only be used in a research atmosphere by qualified professionals.  Despite this many bodybuilders in the modern world seek the assistance of growth hormone releasing peptides. These peptides have the ability to let them experience a boost in appetite about 20 minutes after the injection. A single pulse will last for around 30 minutes and another one will not be generated for the next three hours.

What are the different types of Growth hormone release peptides that can be found out there?

The available growth hormone release peptides can be divided into four major categories. They are:

·         Ipamorelin – Ipamorelin is the gentlest growth hormone releasing peptide that can be found. It does not have the ability to increase prolactin or cortisol level at any dose.

·         GHRP-6 – This is one of the more potent and effecting growth hormone releasing peptides available for the modern world. GHRP-6's affect on prolactin or cortisol level is very dose dependent.  

·         GHRP-2 - GHRP-2 is slightly more potent when compared to GHRP-6. It can also deliver a stronger effect to your hormones at all dosage levels. In other words, GHRP-2 gives life to a high normal range of prolactin or cortisol.

·         Hexarelin – Hexarelin is slightly harsher than GHRP-2 and it can be considered as the strongest growth hormone release peptide out of the list. Therefore, Hexarelin can deliver the strongest impact on prolactin and cortisol levels at all dosage levels.

All these growth hormone releasing peptides can get desensitized by having a constant usage throughout the entire day. However, you should note that GHRP-6 and Ipamorelin do not desensitize when there are short breaks in between. The highest potency GHRP, Hexarelin desensitize without any regard to the dosage. Therefore, research has shown test subjects experience its effect for a period of 14 days.

Can GHRPs be used alone?

Yes. GHRPs can create larger pulse of growth hormone on their own when compared to growth hormone releasing hormones. This is done with enhanced predictability and consistency. Therefore, GHRPs are often used alone in research protocols.

What is the typical protocol for GHRH?

From the studies, it has been identified that the typical conversion of protocol would be around 5 to 7 days a week with subcutaneous injections. Typical dosage of approximately 100 to 200mcg of it per one dose.  The number of intakes per day is sometimes increased in order to test increased effectiveness.

No adverse effects have been reported with the continuous usage of growth hormone release peptides.  The results delivered by GHRPs are effective and they have the ability to deliver long lasting results to the users without much hassle.  Many people are encouraged by the results of the studies and research performed using GHRPs and look forward to increased research into these peptides.

PT-141 – The Perfect Aphrodisiac?

PT-141 (Bremelanotide)

PT-141 (or Bremelanotide) which is developed from Melanotan II, is a new drug which treats sexual dysfunction in both men and women. PT-141 and Melanotan II are said to be true aphrodisiacs, in the classical sense of the term.

Melanotan II is an artificially produced variant of a peptide hormone that stimulates melanogenesis, known as the alpha-Melanocyte stimulating hormone. 

PT-141 has picked up the reputation of being the only effective synthetic aphrodisiac in the market. Many clinical trials have been done that show how PT-141 can be an effective cure for men suffering from sexual dysfunctions such as Erectile Dysfunction and impotence. It has wonderful benefits for women as well, as it is believed to have the potential to cure sexual arousal disorder, which affects many women.

Drugs such as Viagra, Levitra and Cials are not exactly aphrodisiacs; they don’t have a direct effect on the libido. PT-141 is an aphrodisiac and helps with the libido. It can have a synergistic effect if used in a combination with PDE5 inhibitors.

PT-141 is based on Bremelanotide, a known aphrodisiac. Bremelanotide is a melanocortin peptide hormone. It binds itself to the melanocortin 4 receptor in the brain, which causes sexual arousal in women. 90% of the participants in various tests have claimed to experience a strong sexual arousal.

What PT-141 does is to target the brain’s arousal center. In some of the initial tests done on lab rats, it was found that administering PT-141 in female rats threw them into a state of extreme sexual arousal, so much that they became sexually aggressive with the males.

Can PT-141 cause instant sexual arousal in women with low libido, who are generally indifferent to sexual desires? Well, scientists working at Palatin Technologies say that a nasal spray with PT-141 used by them sent female participants in the trials into a state of high sexual arousal.

In around three years, Palatin Technologies hopes to sell PT-141 to the public, to treat men and women with sexual issues - impotence and ED in men and low sexual arousal in women.

This is of a particular benefit to women. It is believed that 40% of women have issues with sexual arousal – while they are interested in sex, they find it hard to reach climax. This could also be the answer many men are looking for, as nobody likes having a partner who is not sexually aroused by you. Could PT-141 be the magical glue that saves marriages around the world?

In another study conducted at the New Jersey's University of Medicine and Dentistry, of the 32 healthy female participants, 16 were given PT-141 and 16 were given a placebo. All women were shown videos with sexual content and had detectors on them that measured the blood flow in their sexual organs.

The women on placebos showed no great reaction, but women on PT-141 had great increases in the blood flow. So, clearly, this is a drug that works as a true aphrodisiac and helps women with their arousal problems. For PT-141 to really work, the woman has to have at least some intention of having sex with a man – it cannot make a woman who has no interest in a man suddenly want to have sex with him. The woman has to be half-way there already if PT-141is to be effective.

So far PT-141 can only be had as a nasal spray and injection. It is hoped that it can be had as pills in the future, which is obviously a more convenient way of taking a drug.

Melanotan II and It's Many Uses

Melanotan II (Melanotan 2)

Melanotan II is an exciting peptide that was created at the University of Arizona in the 1990's.  As was previously covered it is a synthetic analog of a-MSH and was developed to trigger sunless tanning with out the risk of melanoma from the harmful UV rays.  There have been numerous studies conducted since it's inception with some incredible results.  Melanotan II is not currently approved for human use by the FDA but there are still ongoing studies.  These studies have been very interesting.  The Melanotan II studies have shown a great increase in melanogenesis (tanning) through stimulating the melanin production.  The Melanotan II peptide has been able to stimulate the melanocytes into this production.  The melanin production within the skin has been able to protect against many types of skin cancer besides enabling the subjects to show a tan to protect from the UV damage.  While this is a rather exciting advancement Melanotan II has not shown ability to protect from the most dangerous skin cancer (malignant melanoma).  This type of cancer has been shown to primarily develop due to damages in the DNA structure of the skin cells.  Even with out this protection many people are anxious for the approval of Melanotan II for cosmetic use as a solution to avoid the hazards of tanning beds.
Melanotan II has also shown powerful aphrodisiac effects.  In clinical trials Melanotan II has shown an increase in spontaneous erections as well as erection rigidity.  It also increased sexual desire in the subjects by 80%.  These studies are remarkable in that they were conducted in double blind placebo controlled crossover design.  There were side effects of yawning and some nausea in the subjects that are consistent with previous study designs.  The subjects used in the study all suffered from psychosomatic and organic erectile dysfunction.  This has led researchers to believe that as positive as the results have been regarding Melanotan II in the tanning sphere, the true market breakthrough could be for use as an aphrodisiac agent.  The excitement for Melanotan II has been consistently growing across the world and it's value and usage could only increase as further studies are conducted.