Showing posts with label GHRP. Show all posts
Showing posts with label GHRP. Show all posts

Thursday, September 10, 2015

GHRP-6 in Bodybuilding

Peptides in Bodybuilding – GHRP-6

GHRP or Growth Hormone Releasing Peptides are popularly used in the bodybuilding profession because of their ability to act on the pituitary gland and the hypothalamus and trigger the release of Growth Hormone (GH). In fact, GHRPs cause the pituitary gland to release 7 to 15 times as much Growth Hormone as it would have done under normal circumstances.
Growth Hormone or Human Growth Hormone, as it is called, helps to combat the effects of aging, build muscle mass, burn fat and aid in muscle recovery following an intense workout. That’s why GHRPs such as GHRP-6, which we are going to discuss here, as well as GHRP-2, Hexarelin and Ipamorelin are so popular.
GHRP-6 is a much better and safer alternative to synthetic Growth Hormones. It increases the appetite, reduces inflammation, and helps one recover faster from injuries.
In most clinical trials, GHRP-6 has been found to be one of the most effective GHRPs, triggering the release of Growth Hormone quite easily. However, GHRP-6 is arguably less effective than GHRP-2. GHRP-2 is also known to help with faster fat burning in addition to developing bigger muscles because taking GHRP-2 does not create a corresponding increase in appetite.
Taking GHRP-6, on the other hand, causes an increase in appetite. While GHRP-6 is equally effective for muscle building, it should be taken by a bodybuilder who is looking to bulk up rather than one who is trying to cut down. This is the essential difference between GHRP-2 and GHRP-6.
GHRP-6 Benefits…
Ø Bigger and more impressive muscles
Ø Greater physical strength
Ø More stamina, greater endurance
Ø Fast fat burning
Ø Increase in bone density, much better bone tissue growth
Ø Boosts production of IGF-1 by the liver, necessary for faster fat loss
Ø Slows down the aging process
Ø Boosts immunity to disease
Ø Stronger joints and connective tissue.
Ø Reduces the production of Ghrelin, which causes weight gain and builds up insulin resistance
How should you take GHRP-6?
GHRP-6 can be taken in the form of injections or as an oral spray. It should be taken one to three times a day, based on your doctor’s advice. If you’re taking GHRP-6 for bodybuilding, you should take it 3 times a day. This helps with faster fat loss and better development of muscles. GHRP-6 should never be taken on an empty stomach. When taken in the form of injections, it should be applied directly under the skin in the fleshy regions of the body, such as in the stomach, buttocks, thighs, or into the shoulders and biceps.
Taking GHRP-6 with CJC-1295
For added effect, GHRH or Growth Hormone Releasing Hormones such as CJC-1295 may be used in conjunction with GHRP-6. You can, for instance, take 100 mcg of CJC-1295 with 100 mcg of GHRP-6. This would release a tremendous amount of growth hormones, which really helps with maximum muscle building.
What are the Side Effects of GHRP-6?
There are serious side effects related to GHRP-6 at all. It is actually one of the mildest GHRPs out there and so is perfectly safe for all purposes. You should not take GHRP-6 in excess of the recommended dosage as that would cause water retention, tiredness, numbness and tingling in the extremities. It is certainly a much safer alternative to taking Growth Hormone synthetically, which is known to cause many serious side effects.
For more information on GHRP-6 visit here: http://www.knightpeptide.com/2015/06/ghrp-6-new-advances-in-hgh-stimulation.html 


Monday, August 24, 2015

Peptides for Bodybuilding: GHRP-6, GHRP-2, and CJC-1295


Peptides for Bodybuilding: Using GHRP-6, GHRP-2 and CJC-1295
Many athletes and bodybuilders who use growth hormone (GH) hate the fact that it costs them a small fortune to get quality growth hormone. GHRP or Growth Hormone ReleasingPeptides work as a better alternative, as they provide all the benefits of GH, at a fraction of the cost.
There are a plenty of studies that show how GHRPs such as GHRP-2 and GHRP-6 build lean muscle tissue and help shed body fat. Here, we take a closer look at GHRP, and in particular at GHRP-2 and GHRP-6 and their benefits for bodybuilding.
So, What Does GHRP Do, Exactly?
Quite simply, GHRP signals the pituitary gland to secrete growth hormone. While both GHRP-2 and GHRP-6 trigger the release of GH, there is a difference in how they function. GHRP-6 speeds up digestion, which results in more hunger, causing a greater consumption of food.
GHRP-2 is more intense and secretes growth hormones in greater quantity, the effects of which last much longer. GHRP-2 is more effective for bodybuilding as it helps build amazing muscle mass while not increasing appetite, and so helps to shed fat as well. GHRP-6 is useful to those who are looking to bulk up and increase weight. It ensures that much of the weight that gets added is pure muscle.
How to Take GHRP-2 and GHRP-6?
You only have to take a single dose of GHRP-2 or GHRP-6, an hour before your workout, on an empty stomach.  GHRPs have several benefits and they are not limited to bodybuilding. They help combat effects of aging, provide for better sleep and help with faster recovery from injury or tiredness after an intense workout.
For added effect, you may take multiple doses of GHRP-2 or GHRP-6, but be sure to consult with your doctor before you start doing so. After taking GHRPs, you shouldn’t eat for at least a couple of hours, to allow for the body to burn the fat stores as fuel. GHRP-2 and GHRP-6 help with both muscle development and fat burning.
Why Not Take Growth Hormone Directly?
The simple reason why you shouldn’t buy GH directly is because it is expensive. And much of the GH sold in the market is counterfeit, made by shady manufacturers based in China and elsewhere. You would be better off buying GHRPs from reputable companies.
Use CJC-1925 for Added Benefit
In addition to using GHRPs, you may want to consider having a GHRH (or growth hormone releasing hormone) such as CJC-1295 as your pre-workout diet as well. GHRH is a natural hormone that works closely with ghrelin to stimulate the release of growth hormone.
While GHRH cannot be used directly, it is available in the form of derivatives such as CJC-1295. CJC-1295 is long-lasting and quite effective for muscle building and weight loss. You may want to take100 mcg of CJC-1295 together with 100 mcg of a GHRP-2 or GHRP-6 two to three times a day, around half-an-hour before a meal for maximum effect.

Taking CJC-1295 and GHRPs (either GHRP-2 or GHRP-6) together is highly desirable because the combination produces more growth hormones than what you would get had you taken GHRP alone. So this is something you should consider if your body is able to tolerate high GH levels.


Thursday, July 16, 2015

GHRP-2 Vs GHRP-6

GHRP-2 and GHRP-6: A Comparison

GHRP-2 and GHRP-6

Whether you’re an athlete, bodybuilder or just a fitness enthusiast, you should consider taking the peptides GHRP-2 and the GHRP-6, as they not only help reduce body fat, also produce amazing muscle gains. GHRP-2 and GHRP-6 belong to the family of GHRP peptides. GHRP stands for Growth Hormone Releasing Peptide.
What these peptides do is to trigger the release of Human Growth Hormone (or HGH) by the body, which is so essential for fat loss, muscle growth and slowing down the process of aging. The best time to take GHRP-2 and GHRP-6 is when you are on a systematic and disciplined diet and exercise program. The combination of GHRPs, diet and exercise is incredibly effective and helps to transform your body completely in super quick time.
While GHRP-2 and GHRP-6 are similar in a lot of ways, there are subtle differences between them. One of the biggest differences is that GHRP-6 increases your hunger pangs, makes you want to consume more food, especially when you take the supplement regularly.
GHRP-2, on the other hand, does not make you crave for food, which is why it is far more effective if it is your primary goal to shed weight. However, if it is your goal to get bigger, but in a healthy way, adding only muscular growth, without a corresponding increase in body fat, then GHRP-6 would suit you better.
GHRP-2 is also slightly stronger than GHRP-6 and releases more growth hormones. So, selecting GHRP-2 instead of GHRP-6 would make sense if you’d want more growth hormones to be released by your body.
GHRP-2 has a short half life, unlike GHRP-6. The effects of GHRP-2 reach their peak within 15 minutes of taking the drug. The effects of GHRP-6 last much longer.
GHRP-2 controls the release of prolactin and Cortisol better than GHRP-6. However, since GHRP-6 has very little effect on prolactin and Cortisol levels, some prefer it to GHRP-2. But this varies from one individual to another and the decision is usually based on a doctor’s advice.
GHRP-2 and GHRP-6 are typically similar and cost. They are very cost efficient supplements for a bodybuilder.
GHRP-2 helps improve calcium level in the body, which in turn helps with the secretion of growth hormones. In fact, GHRP-2 is the most effective peptide when it comes to the secretion of growth hormones in the body, which is why it is recommended for the treatment of catabolic deficiencies.
Both GHRP-2 and GHRP-6 have their distinct advantages and disadvantages. So it is basically up to individual choices and needs when it comes to choosing between them. You should always consult with your physician before deciding whether to take GHRP-2 or GHRP-6.
However, regardless of which supplement you choose, it is important to be patient and stick to the recommended dosage always. The desired results – with either GHRP-2 or GHRP-6 - will be visible only you are motivated and disciplined enough to stick to a proper diet and an effective workout plan.

Wednesday, July 15, 2015

Ipamorelin and Fat Loss

Ipamorelin and Fat Loss

Ipamorelin is a new muscle building peptide from the GHRP family of peptides, which is making a lot of news in the bodybuilding and athletic community. Ipamorelin triggers the release of HGH or Human Growth Hormone, which is so essential for muscle growth and development, fat loss, anti-aging and other benefits. In fact, scientists say that the Human Growth Hormone released by Ipamorelin is of a particularly strong variant. Here, we focus on Ipamorelin and fat loss, in particular.

How does Ipamorelin Work?
The effects of Ipamorelin are so amazing that it is still being studied by researchers around the world. Scientists are still trying to understand how exactly it helps with muscle growth and weight loss. So far, the findings have been very positive. What happens is that when Ipamorelin triggers the release of growth hormones, this causes the faster development of the cells in the muscle tissue, without affecting the bones or the cartilages. Ipamorelin triggers the natural development of growth hormones by the body for faster muscle development.

Ipamorelin and Fat Loss – How Effective is it?
Ipamorelin is highly recommended to those who are looking to shed fat. With Ipamorelin, you gain in muscle mass, but not in body fat. In fact, the peptide has been tested extensively on laboratory rats.
It was found that it increased the body weight of the rats, but almost of the body weight comprised entirely of muscular growth. All the unnecessary fat had been lost and there were no indications of bone or cartilage deformity.
Ipamorelin suppresses the appetite and cuts down the constant craving one may have for food. That’s why it is so useful for fat loss. Fat loss with Ipamorelin is also very healthy because the fat is replaced with muscle.
For Ipamorelin to work, it should be injected in small amounts, so that it is released very slowly in the body. This keeps hunger away and builds muscle at the same time. Ipamorelin does not raise your Cortisol and Prolactin levels suddenly, which makes it so much more effective for fat loss.

How to take Ipamorelin?
Ipamorelin should be taken as a subcutaneous injection, just two or three times a day. It should be injected in the stomach, buttocks or in any fleshy part of the body. Ipamorelin should be taken 45 minutes before a workout. It should always be stored in a cool, dry place and away from sunlight.
Are there any Ipamorelin Sides Effects?
Ipamorelin is largely safe, but it does have a couple of side effects. These include headaches and dizziness. That’s why the best way to take Ipamorelin is to take it in the smallest dose possible and gradually build up the dosage after a few weeks.

The Bottom Line
Ipamorelin and fat loss are closely linked, and this is because those who take Ipamorelin lose fat in a healthy way, by converting fat into muscle. It is also a terrific pre-workout as well as post-workout drug. It’s no surprise that it is such a big hit with the health and fitness industry.

Tuesday, June 30, 2015

Hexarelin: Growth Hormone Releasing Peptide

Hexarelin: Growth Hormone Releasing Peptide
Hexarelin is a part of the GHRP family of peptides that act on the pituitary gland and the hypothalamus to release Human Growth Hormone (HGH). The various GHRP (or Growth Hormone Releasing Peptides) were discovered in the 1990’s and since then have been subjected to extensive clinical research.
GHRPs such as GHRP-2, GHRP-6, Ipamorelin and Hexarelin stimulate the pituitary gland to produce endogenous Growth Hormone (or GH). They are all similar drugs with a similar action. Among all the GHRPs, Hexarelin is the strongest. It is known to produce a powerful GH secretion. It is also known to increase cortisol and prolactin level.
Hexarelin is the recommended medication for GH deficiency.  Hexarelin is quite popular with professional athletes as a performance enhancement drug. One of the major advantages of taking Hexarelin, compared to other GHRPs such as GHRP-2 and GHRP-6 is that it does not lead to an automatic increase in appetite. This is because Hexarelin does not increase the Gherelin levels by any great extent. Ghrelin is, of course, responsible for increased hunger and faster gastric emptying.

 Let’s see what are the main benefits of taking Hexarelin.
Ø It builds up physical strength and stamina
Ø It stimulates the growth of new muscle fibers
Ø It speeds up the growth the muscle fibers that are already in the body
Ø It offers excellent protection to the body’s joints
Ø It helps to reduce the amount of fat in the body
Ø It makes the skin more elastic
Ø It increases bone density
Ø It helps to recover faster from injuries


How Does Hexarelin Work?
The application of Hexarelin into the body leads to several natural functions. First, Hexareline circulates the growth hormones in the body. It stimulates the secretion of IGF-1 by the liver. IGF-1 means Insulin like Growth Factor. An increase in IGF-1 stimulates faster muscle growth.
Hexarelin is quite the same as GHRP-6 structurally, but does not induce hunger like GHRP-6 does. Hexarelin helps to reduce the amount of fat in adipose tissues. Hexarelin helps protect neural activity in the central nervous system as well.
Who Uses Hexarelin?
Hexarelin is recommended to those who are deficient in the Growth Hormone. It is taken by older men and women to slow down the aging process. Athletes are the most common users of Hexarelin because of how it helps with fat loss and muscle growth. It is taken by men and women who wish to lose weight fast as well. Hexarelin makes the skin more elastic, which is why it is popular with those looking for a younger looking skin. Hexarelin is also taken by bodybuilders who are looking to shed fat and gain muscle mass.
How to take Hexarelin?
Hexarelin should be taken 1 to 3 times a day, and no more than that.  If you are taking Hexarelin for fat reduction or muscle gain, you may have it two to three times a day. If you’re taking it for other reasons, such as to slow down aging or to make the skin more elastic, you shouldn’t take Hexarelin more than once a day. Hexarelin should be taken in the form of subcutaneous injections, but never on an empty stomach. It should be injected directly under the skin into the stomach, thighs, or buttocks, or into the biceps and shoulders.

What are the side effects of Hexarelin?

Hexarelin is a powerful peptide, not as mild as other GHRPs such as Ipamorelin. Hexarelin must be taken well within its recommended dosage, otherwise it could cause water retention, tightness in the muscles, or even carpal tunnel-like symptoms. It may also cause numbness and tingling in the extremities, a decrease in insulin sensitivity and exhaustion. However, none of the Hexarelin side effects are as severe as those caused by the intake of synthetic Human Growth Hormone.

Friday, June 26, 2015

GHRP-2 and the Fountain of Youth

GHRP-2

GHRP-2 belong to a family of peptides that were discovered back in the 1990’s as synthetic tissue derived amino acids.  GHRPs such as GHRP-2 act at the pituitary and the hypothalamus to release the Human Growth Hormone (HGH) by activating a G protein-coupled receptor.
In most clinical studies, GHRP-2 was found to be the most powerful GHRP that stimulated the pituitary glands’ natural production of HGH. GHRP-2 was found to boost the hypothalamus function as well.
A GHRP-2 therapy, that releases Human Growth Hormones (HGH), is one of the most effective ways of slowing down the process of aging in adult men and women.
Let’s look at some of the benefits of GHRP-2:
Ø It cuts down belly fat through lipolysis
Ø It increases the sex drive by stimulating the hypothalamus
Ø It improves protein synthesis
Ø It improves eyesight and vision
Ø It reduces liver uptake of glucose, which is the opposite of what insulin does
Ø It boosts energy and vitality
Ø It helps to improve the skin elasticity and reduces wrinkles
Ø It makes the heart stronger and healthier
Ø It makes the immune system stronger
Ø It boosts stamina and increases endurance
Ø It speeds up the recovery from wounds or surgery
Ø It boosts the IGF-1 production by around 50% in the first week of use itself
Ø It helps you get good, sound sleep
Ø It increases your calcium retention, improves bone density and strengthens and enhances the mineralization of bone
Ø It helps with liver glucogenesis
Ø It helps improve the functionality of the pancreatic islets
There have been several clinical studies, such as one published in the Journal of Endocrinology and Metabolism in 1997 that show how a medically supervised therapy involving GHRP-2 increased growth hormone levels in both adults and children, and helped addressed issues related to growth hormone deficiency. It was found that the GHRP-2 therapy led to an increase in the body’s growth hormone, because of much higher IGF-1 levels. This has an anabolic effect on the tissues as well as several other benefits, as listed above.
How does GHRP-2 Work?
GHRP-2 activates the pituitary gland, which results in an increase in the production of the endogenous growth hormone. GHRP-2 enhances the body’s growth hormone naturally, without any of the side effects associated with synthetic hormone use.
GHRP-2 boosts HGH production in a two-step process:
Ø By boosting the growth hormone through an amplification of the transduction pathway which releases a hormone signal.
Ø By suppressing somatostatin, which results in an increase in the endogenous growth hormone levels.
GHRP-2 has to be administered daily, though subcutaneous injections, orally or by an intra-nasal route. For enhanced effect, GHRP-2 has to be used in conjunction with GHRP-6 and Sermorelin, which perform an action similar to it, which is to activate the pituitary gland to manufacture higher natural human growth hormone. This aids the functionality of the hypothalamus as well.
How Safe is GHRP-2?

GHRP-2 is considered to be a safe alternate to synthetic Human Growth Hormone, and it has been tested in several clinical trials. HGRP-2 has been approved by a number of scientists. What is important is to take GHRP-2 within the suggested dose, strictly adhering to your doctor’s advice. It is very important not to take GHRP-2 excessively as that might lead to side effects such as water retention, exhaustion or numbness and tingling in the extremities. GHRP-2 is certainly a better alternative to synthetic Human Growth Hormone (HGH) which is known to have too many side-effects.

Wednesday, June 24, 2015

Ipamorelin: Growth Hormone Releasing Peptide of the Future

Ipamorelin: Growth Hormone Releasing Peptide of the Future

Ipamorelin

Ipamorelin is the latest muscle building peptide supplement recommended for bodybuilders and professional athletes. Ipamorelin belongs to the family of peptides known as GHRPs, that are known to act on the pituitary gland and stimulate the production of the Human Growth Hormone – which is essential for muscle growth.
Ipamorelin is the cleanest, safest and the most versatile GHRP out there. It is very similar to another GHRP called Hexarelin, but much milder. It performs the same action as GHRP-2 and GHRP-6, but without their side effects such as a spike in appetite. The GH (Growth Hormone) released by Ipamorelin is known to be particularly potent and effective for muscle gains and weight loss.
Many clinical tests have been done on Ipamorelin, and so far the peptide appears to be safe, with a pronounced effect on weight loss and muscle gain. The Growth Hormones released by Ipamorelin help with faster muscle growth, while avoiding bone or cartilage distortions.

Let’s look at some of the benefits associated with Ipamorelin.

Boosts Growth Hormone levels in the body
Ipamorelin is one of the best promoters of Human Growth Hormone in the market and stimulates the production of HGH naturally. It works by binding itself to the G protein-receptors in a cell and triggers release of HGH.

Reduces Appetite, Unlike Other Peptides
Ipamorelin is different from other peptides in the GHRP family because it does not raise hunger levels significantly. It increases the growth of muscle and reduces body fat. With Ipamorelin, you can stick to your diet without having to suffer from hunger pangs.

 Increases the Body Weight the Healthy Way

How does it Work?


Ipamorelin is recommended to those looking to gain body weight, but the healthy way. With Ipamorelin, you will gain in muscle mass, not body fat. While studying the effects of Ipamorelin, scientists tested the peptide on rats. It was found that it led to an increase in body weight of the rats, along with a faster muscle growth with zero bone deformity risk.

When you inject Ipamorelin into the body, a pulse is generated that stimulates the pituitary gland or the hypothalamus, causing the release of GH.  This pulse endures for 3 hours following the injection of Ipamorelin. Once the pulse is sent, the cells go directly into the development of muscle while staying away from any bone or cartilage growth. So there is no likelihood of a bone deformity happening when you take Ipamorelin. For this reason, Ipamorelin is preferable to synthetic HGH, which is known to cause swelling of the joints. Ipamorelin causes fat loss, provides much needed nutrition and builds clean muscle mass.

How to take Ipamorelin?
It should be administered by a subcutaneous injection, no more than two or three times a day. It can be injected in the stomach, buttocks or any fleshy part of the body. Ipamorelin should be stored in a cool, dry place such as a refrigerator.

Are there any Ipamorelin Sides Effects?
Ipamorelin is actually the mildest and safest of all peptides in the GHRP family and has no serious side effects. However, high doses of Ipamorelin can increase cortisol or acetylcholine levels. This may cause simple side effects such a slight dizziness or minor headaches, when Ipamorelin is taken in excess.  Ideally, Ipamorelin should be taken 45 minutes before a workout.  

More information on GHRPs:  http://www.knightpeptide.com/2015/06/growth-hormone-releasing-peptides-or.html


Monday, June 22, 2015

GHRP-6 - New Advances in HGH Stimulation

GHRP-6

In many clinical tests, GHRP-6 has been found to be very effective at stimulating the pituitary glands’ natural production of HGH. It is an injectable peptide which falls in the category of GHRPs or growth hormone releasing peptides.
GHRPs are peptides that were discovered 20 years ago as synthetic tissue derived amino acids.  GHRPs act on the pituitary and the hypothalamus, and activate a G protein-coupled receptor, which results in the release of the Human Growth Hormone (HGH).
All GHRPs, including GHRP-6 work to produce Human Growth Hormone naturally.  GHRP-6 can be used alone or in a combination with other peptides in this category, such as GHRP-2, Hexarelin, and Ipamorelin. All GHRPs are similar in properties and functionality.
GHRP-6 increases the Growth Hormone levels, which leads to an increase in the IGF-1 level. This helps with faster fat loss and with muscle gains as well. GHRP-6 is used as a safer alternative to synthetic Growth Hormones. It is known to increase appetite, reduces inflammation, and helps one recover faster from injuries.
Who may benefit from GHRP-6?
GHRP should be taken by:
Ø Bodybuilders -Perfect for bodybuilders who are looking to get bigger and build muscle mass
Ø Dieters - Ideal for those who are looking to shed body fat
Ø Seniors- Considered beneficial to older people because of its anti-aging benefits

Let’s look at some of the benefits of taking GHRP-6.
Ø Impressive gains in muscle mass
Ø More strength and stamina
Ø Shedding of body fat
Ø Greater bone density and better bone tissue growth
Ø Helps with the production of IGF-1 by the liver, which results in faster loss of fat
Ø It slows down the process of aging.
Ø Boosts immune response
Ø Builds up strength in the joints, connective tissue, and body mass
Ø Known to inhibit Ghrelin, which is known to cause weight gain and insulin resistance
When would be proper dosing of GHRP-6?
GHRP-2 should be taken for the same purpose for which you may want to take GH for. But it is preferable to take GHRP-6 when GH is not available, or when you would rather have your body stimulate GH on its own than inject GH artificially. GHRP-6 may be used in a combination with anabolic steroids for massive muscle gains and faster recovery from injury. When taking GHRP-6 as a part of a fat loss program, it is recommended to stick to the minimum dosage, as far as possible. You may take GHRP-6 in combination with other GHRPs or with GH for maximum benefit.
How much GHRP-6 should you take?
GHRP-6 should be taken 1 to 3 times a day, based on your goals. If you are taking GHRP-6 for fat reduction or muscle gain, you should take it thrice a day, and if you’re taking it for its anti-aging properties, you shouldn’t take GHRP-6 more than once a day. GHRP-6 would be taken as injections, but never on an empty stomach. It would be applied directly under the skin into the stomach, thighs, or buttocks, or into the biceps and shoulders.
What are the Side Effects of GHRP-6?

GHRP-6 has no serious side effects. It does cause an increase in appetite, which you should guard against. Otherwise, GHRP-6 is perfectly safe, and a much better alternative to synthetic GH, which is known to have many harmful side effects.


Tuesday, April 14, 2015

What are Peptides?

Peptides are naturally occurring biological molecules.  They are short chains of amino acid monomers linked by peptide bonds.  Peptides are distinguished from proteins on the basis of size.  This number is usually distinguished by 50 or fewer amino acids.  Proteins are polypeptides that are more complex.  Intake and production of all the amino acids is necessary for the production of all the peptides needed for the body to operate efficiently.

Peptides are created through peptide synthesis.  This is the combination of amino acids that are connected through peptide bonds.  Peptides are synthesized by coupling the carboxyl group or C-terminus of one amino acid to the amino group or N-terminus of another. There are two strategies for peptide synthesis: liquid-phase peptide synthesis and solid-phase peptide synthesis.


In 1901 the first synthetic peptide was discovered by Emil Fischer working with Ernest Fourneau.  It was not until 1953 that the first polypeptide was synthesized by Vincent de Vigneaud.  This peptide synthesized by de Vigneaud is the popularly know Oxytocin.  Oxytocin is produced naturally in the brain by the hypothalamus where it is transported out before being secreted by the pituitary gland.  This peptide serves many purposes in the reproductive cycle such as triggering child birth and also during breast feeding.  This peptide also creates a sense of trust and well being in the brain.  


Peptides have a wide range of applications in medicine and biology.  They are what regulate most physiological process of the body.  From the endocrine system to growth factors and neurotransmitters, peptides signal the body in numerous ways.  Insulin was the first therapeutic protein to be introduced to help treat Diabetics in the 1950's.  Since then over 60 different peptide drugs have been approved by the FDA for use.  There are about 140 currently in clinical trials and another 500+ peptide drugs in pre-clinical development.

Knight Peptide will continue to explore the world of peptides and be a place of education.